Comodo has made itself a name in the industry for virus protection, and appears on the surface to contain most items necessary to provide good protection.

Its really simple to use. I didnt have to do much fiddling around to set it up. It also has a really good option where you can run suspicious files in a sandbox environment. I get a lot of email attachments from clients and despite taking best precautions the threat of opening an attachment that contains malicious stuff is very real. The sandbox protection was really great for scenarios like that. If you get an attachment and you arent sure if its a legit file or malware, just open it in sandbox mode to see what it is. You can also automate this sandbox to make life a little easier. I was also pretty happy with how little it impacted the performance of my system. I didnt see any significant slowdowns even when a scan was ongoing. The interface is also really nice. I could find everything I needed to find with a few clicks. If you are an intermediate user like me, you will have no trouble navigating and using it.

Easy to setup server and clients. Easy to deploy profiles and rules in order to separate out clients and server etc. for better security and reportiong.